| Saturday, October 9, 2021 | 6:00pm | HKY | Arizona State Sun Devils at Denver Pioneers | Altitude |
| Friday, November 12, 2021 | 7:00pm | HKY | Western Michigan Broncos at Denver Pioneers | ALT2 |
| Saturday, November 13, 2021 | 6:00pm | HKY | Western Michigan Broncos at Denver Pioneers | ALT2 |
| Friday, November 19, 2021 | 7:00pm | HKY | Miami RedHawks at Denver Pioneers | ALT2 |
| Saturday, November 20, 2021 | 6:00pm | HKY | Miami RedHawks at Denver Pioneers | Altitude |
| Wednesday, December 15, 2021 | 7:00pm | CBK | UC San Diego Tritons at Denver Pioneers | ALT2 |
| Monday, December 20, 2021 | 7:00pm | CBK | Western Illinois Leathernecks at Denver Pioneers | ALT2 |
| Saturday, January 1, 2022 |
6:00pm |
HKY |
Alaska-Fairbanks Nanooks at Denver Pioneers |
ALT2 |
| Thursday, January 6, 2022 |
7:00pm |
CBK |
North Dakota State Bison at Denver Pioneers |
ALT2 |
| Saturday, January 8, 2022 |
2:00pm |
CBK |
North Dakota Fighting Hawks at Denver Pioneers |
ALT2 |
| Friday, January 21, 2022 |
7:00pm |
HKY |
Colorado College Tigers at Denver Pioneers |
ALT2 |
| Thursday, January 27, 2022 |
7:00pm |
CBK |
Kansas City Roos at Denver Pioneers |
Altitude |
| Thursday, February 3, 2022 |
7:00pm |
WBK |
North Dakota Fighting Hawks at Denver Pioneers |
Altitude |
| Thursday, February 10, 2022 |
7:00pm |
CBK |
South Dakota State Jackrabbits at Denver Pioneers |
Altitude |
| Friday, February 11, 2022 |
7:00pm |
HKY |
Minnesota-Duluth Bulldogs at Denver Pioneers |
ALT2 |
| Saturday, February 19, 2022 |
2:00pm |
WBK |
Omaha Mavericks at Denver Pioneers |
Altitude |
| Friday, February 25, 2022 |
7:00pm |
HKY |
Omaha Mavericks at Denver Pioneers |
ALT2 |
| Saturday, March 5, 2022 |
7:00pm |
HKY |
Colorado College Tigers at Denver Pioneers |
ALT2 |
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